Highlights:

Highlights
Biol Reprod 2008 78: 957. [Full Text] [PDF]  

Embryo:

Masahiko Ito, Tomohide Shikano, Shoji Oda, Takashi Horiguchi, Satomi Tanimoto, Takeo Awaji, Hiroshi Mitani, and Shunichi Miyazaki

Difference in Ca²⁺ Oscillation-Inducing Activity and Nuclear Translocation Ability of PLCZ1, an Egg-Activating Sperm Factor Candidate, Between Mouse, Rat, Human, and Medaka Fish
Biol Reprod 2008 78: 1081-1090. [Abstract] [Full Text] [PDF]  

Summary: Nuclear translocation ability of PLCZ1 is not common property for the cessation of Ca2+ oscillations

Female Reproductive Tract:

G.D. Orvis, S.P. Jamin, K.M. Kwan, Y. Mishina, V.M. Kaartinen, S. Huang, A.B. Roberts, L. Umans, D. Huylebroeck, A. Zwijsen, D. Wang, J.F. Martin, and R.R. Behringer

Functional Redundancy of TGF-beta Family Type I Receptors and Receptor-Smads in Mediating Anti-Müllerian Hormone-Induced Müllerian Duct Regression in the Mouse
Biol Reprod 2008 78: 994-1001. [Abstract] [Full Text] [PDF]  

Summary: Two TGF-beta type I receptors (ACVR1 and BMPR1A) and all three BMP receptor-mediated SMADs (SMAD1, 5, and 8) function redundantly in transducing the anti-Mullerian hormone signal for Mullerian duct regression

N. Keating and L.R. Quinlan

Effect of Basolateral Adenosine Triphosphate on Chloride Secretion by Bovine Oviductal Epithelium
Biol Reprod 2008 78: 1119-1126. [Abstract] [Full Text] [PDF]  

Summary: Extracellular ATP activates chloride secretion in the bovine oviduct epithelium via calcium-activated chloride channels

Gamete Biology:

Andrew Walsh, Dean Whelan, Amanda Bielanowicz, Brooke Skinner, R. John Aitken, Moira K. O'Bryan, and Brett Nixon

Identification of the Molecular Chaperone, Heat Shock Protein 1 (Chaperonin 10), in the Reproductive Tract and in Capacitating Spermatozoa in the Male Mouse
Biol Reprod 2008 78: 983-993. [Abstract] [Full Text] [PDF]  

Summary: Analysis of the localization of HSPE1 during testicular development, epididymal transit, capacitation, and the acrosome reaction

Tsutomu Endo, Kiyoshi Kano, and Kunihiko Naito

Nuclear Histone Deacetylases Are Not Required for Global Histone Deacetylation During Meiotic Maturation in Porcine Oocytes
Biol Reprod 2008 78: 1073-1080. [Abstract] [Full Text] [PDF]  

Summary: In mammalian oocytes, HDACs present in the nucleus and in the cytoplasm belong to class I and other than class I, respectively, and nuclear contents, including class I HDACs, are not required for the oocyte-specific global histone deacetylation

Male Reproductive Tract:

Pawel Grzmil, Dagmara Boinska, Kenneth C. Kleene, Ibrahim Adham, Gregor Schlüter, Martin Kämper, Byambajav Buyandelger, Andreas Meinhardt, Stephan Wolf, and Wolfgang Engel

Prm3, the Fourth Gene in the Mouse Protamine Gene Cluster, Encodes a Conserved Acidic Protein That Affects Sperm Motility
Biol Reprod 2008 78: 958-967. [Abstract] [Full Text] [PDF] Supplemental Tables  

Summary: Prm3, the fourth gene in the protamine gene cluster, encodes a conserved acidic protein that affects sperm motility.

Mechanisms of Hormone Action:

Catalin Nicola, Peeyush K. Lala, and Chandan Chakraborty

Prostaglandin E₂-Mediated Migration of Human Trophoblast Requires RAC1 and CDC42
Biol Reprod 2008 78: 976-982. [Abstract] [Full Text] [PDF]  

Summary: Small GTP binding proteins RAC1 and CDC42 are required for prostaglandin (PG) E2-mediated human trophoblast migration.

Miao Zhong, Dilyara A. Murtazina, Jennifer Phillips, Chun-Ying Ku, and Barbara M. Sanborn

Multiple Signals Regulate Phospholipase CBeta3 in Human Myometrial Cells
Biol Reprod 2008 78: 1007-1017. [Abstract] [Full Text] [PDF]  

Summary: The regulation of PLCB3-serine1105 phosphorylation by both negative feedback and negative crosstalk facilitates the integration of multiple signaling pathways in myometrial cells

Sagit Sela-Abramovich, Dalia Galiani, Nava Nevo, and Nava Dekel

Inhibition of Rat Oocyte Maturation and Ovulation by Nitric Oxide: Mechanism of Action
Biol Reprod 2008 78: 1111-1118. [Abstract] [Full Text] [PDF]  

Summary: Inhibition of LH-induced oocyte maturation and ovulation by NO involves interference with breakdown of gap junctional communication and suppression of cumulus expansion

Neuroendocrinology:

Rebecca M. Steinberg, Deena M. Walker, Thomas E. Juenger, Michael J. Woller, and Andrea C. Gore

Effects of Perinatal Polychlorinated Biphenyls on Adult Female Rat Reproduction: Development, Reproductive Physiology, and Second Generational Effects
Biol Reprod 2008 78: 1091-1101. [Abstract] [Full Text] [PDF]  

Summary: Fetal exposure to low levels of PCBs disrupts adult reproductive function, and this effect persists to a second generation

Ovary:

Venkataraman Sriraman, Ursula Eichenlaub-Ritter, Jörg W. Bartsch, Andrea Rittger, Sabine M. Mulders, and JoAnne S. Richards

Regulated Expression of ADAM8 (a Disintegrin and Metalloprotease Domain 8) in the Mouse Ovary: Evidence for a Regulatory Role of Luteinizing Hormone, Progesterone Receptor, and Epidermal Growth Factor-Like Growth Factors
Biol Reprod 2008 78: 1038-1048. [Abstract] [Full Text] [PDF]  

Summary: ADAM8 is expressed in a stage-specific manner and is hormonally-regulated in ovulating follicles by the coordinate actions of LH and PGR

M.Y. Yang and J.E. Fortune

The Capacity of Primordial Follicles in Fetal Bovine Ovaries to Initiate Growth In Vitro Develops During Mid-Gestation and Is Associated with Meiotic Arrest of Oocytes
Biol Reprod 2008 78: 1153-1161. [Abstract] [Full Text] [PDF]  

Summary: The capacity of bovine primordial follicles to activate develops during the mid-gestation in association with meiotic arrest of oocytes at the diplotene stage and can be inhibited in vitro by estradiol or progesterone, but not by DHT

Pregnancy:

Joëlle Henry-Berger, Kevin Mouzat, Silvère Baron, Carmelo Bernabeu, Geoffroy Marceau, Jean-Paul Saru, Vincent Sapin, Jean-Marc A. Lobaccaro, and Françoise Caira

Endoglin (CD105) Expression Is Regulated by the Liver X Receptor Alpha (NR1H3) in Human Trophoblast Cell Line JAR
Biol Reprod 2008 78: 968-975. [Abstract] [Full Text] [PDF]  

Summary: The expression of Endoglin, an auxiliary protein of the transforming growth factor beta receptor is up-regulated by the liver-X-receptor alpha in human choriocarcinoma cell line JAR

Pilar Pallares and Antonio Gonzalez-Bulnes

Intrauterine Growth Retardation in Endothelial Nitric Oxide Synthase-Deficient Mice Is Established from Early Stages of Pregnancy
Biol Reprod 2008 78: 1002-1006. [Abstract] [Full Text] [PDF]  

Summary: The processes of fetal growth retardation characteristic of Nos3-knockout mice take place from early pregnancy stages

Zhaoyang Zeng, Michael C. Velarde, Frank A. Simmen, and Rosalia C.M. Simmen

Delayed Parturition and Altered Myometrial Progesterone Receptor Isoform A Expression in Mice Null for Krüppel-Like Factor 9
Biol Reprod 2008 78: 1029-1037. [Abstract] [Full Text] [PDF]  

Summary: The transcription factor Kruppel-like factor 9 contributes to functional progesterone receptor signaling in the myometrium, leading to timely onset of parturition through its regulation of progesterone receptor isoform A expression

Max Gassmann, Annamaria Manini, Thomas Stallmach, Bianca Saam, Gisela Kuhn, Beat Grenacher, Anna Y. Bogdanova, and Johannes Vogel

Abortion in Mice with Excessive Erythrocytosis Is Due to Impaired Arteriogenesis of the Uterine Arcade
Biol Reprod 2008 78: 1049-1057. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Summary: Poor arteriogenesis of the uterine arcade might be a previously unappreciated cause for clinically important pregnancy complications

Stephanie L. Pierce, Jessica D.K. Kresowik, Kathryn G. Lamping, and Sarah K. England

Overexpression of SK3 Channels Dampens Uterine Contractility to Prevent Preterm Labor in Mice
Biol Reprod 2008 78: 1058-1063. [Abstract] [Full Text] [PDF]  

Summary: A decrease in SK3 channel expression towards the end of pregnancy promotes increased contractility during delivery; overexpression of this channel reduces uterine contractility to inhibit preterm labor

Charles J. Lockwood, Ceyda Oner, Yesim H. Uz, Umit A. Kayisli, S. Joseph Huang, Lynn F. Buchwalder, William Murk, Edmund F. Funai, and Frederick Schatz

Matrix Metalloproteinase 9 (MMP9) Expression in Preeclamptic Decidua and MMP9 Induction by Tumor Necrosis Factor Alpha and Interleukin 1 Beta in Human First Trimester Decidual Cells
Biol Reprod 2008 78: 1064-1072. [Abstract] [Full Text] [PDF]  

Summary: Matrix metalloproteinase 9 is upregulated in decidual cells of placental sections from preeclamptic women and in first-trimester decidual cell cultures by preeclampsia-associated cytokines

Mei-Rong Du, Wen-Hui Zhou, Lin Dong, Xiao-Yong Zhu, Yin-Yan He, Jin-Ying Yang, and Da-Jin Li

Cyclosporin A Promotes Growth and Invasiveness In Vitro of Human First-Trimester Trophoblast Cells Via MAPK3/MAPK1-Mediated AP1 and Ca²⁺/Calcineurin/NFAT Signaling Pathways
Biol Reprod 2008 78: 1102-1110. [Abstract] [Full Text] [PDF]  

Summary: Cyclosporin A, an immunosuppressant, can promote growth and invasiveness in vitro of human first-trimester trophoblast cells via differential signal pathways, which may lead to the expansion of the clinical applications of this drug

Testis:

Joseph S. Tash, Barbara Attardi, Sheri A. Hild, Ramappa Chakrasali, Sudhakar R. Jakkaraj, and Gunda I. Georg

A Novel Potent Indazole Carboxylic Acid Derivative Blocks Spermatogenesis and Is Contraceptive in Rats after a Single Oral Dose
Biol Reprod 2008 78: 1127-1138. [Abstract] [Full Text] [PDF]  

Summary: A new nonhormonal reversible antispermatogenic agent shows reversible contraceptive activity in rats

Joseph S. Tash, Ramappa Chakrasali, Sudhakar R. Jakkaraj, Jennifer Hughes, S. Kendall Smith, Kaori Hornbaker, Leslie L. Heckert, Sedide B. Ozturk, M. Kyle Hadden, Terri Goss Kinzy, Brian S.J. Blagg, and Gunda I. Georg

Gamendazole, an Orally Active Indazole Carboxylic Acid Male Contraceptive Agent, Targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and Stimulates Il1a Transcription in Rat Sertoli Cells
Biol Reprod 2008 78: 1139-1152. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Summary: HSP9AB1 and EEF1 are identified as targets in rat Sertoli cells for a new male contraceptive candidate, gamendazole, and a mechanism of action for gamendazole involving disruption of Sertoli cell-spermatid junctions via induction of Il1a is proposed

Toxicology:

Martine Culty, Raphael Thuillier, Wenping Li, Yan Wang, Daniel B. Martinez-Arguelles, Carolina Gesteira Benjamin, Kostantinos M. Triantafilou, Barry R. Zirkin, and Vassilios Papadopoulos

In Utero Exposure to Di-(2-ethylhexyl) Phthalate Exerts Both Short-Term and Long-Lasting Suppressive Effects on Testosterone Production in the Rat
Biol Reprod 2008 78: 1018-1028. [Abstract] [Full Text] [PDF]  

Summary: Fetal exposure to DEHP leads to reduced testosterone levels in the adult by mechanisms that are distinct from those involved in decreased fetal steroidogenesis, suggesting reprogramming of the fetal precursors of adult Leydig cells

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.