Highlights:

Highlights
Biol Reprod 2006 75: 1. [Full Text] [PDF]  

Embryo:

Yufen Xie, Fangfei Wang, Wenjing Zhong, Elizabeth Puscheck, Hayley Shen, and D.A. Rappolee

Shear Stress Induces Preimplantation Embryo Death That Is Delayed by the Zona Pellucida and Associated with Stress-Activated Protein Kinase-Mediated Apoptosis
Biol Reprod 2006 75: 45-55. [Abstract] [Full Text] [PDF]  

Summary: Shear stress induces SAPK/JNK, which induces TUNEL and embryo death.

Female Reproductive Tract:

Piotr C. Piotrowski, Jakub Kwintkiewicz, Izabela J. Rzepczynska, Yasemin Seval, Hakan Cakmak, Aydin Arici, and Antoni J. Duleba

Statins Inhibit Growth of Human Endometrial Stromal Cells Independently of Cholesterol Availability
Biol Reprod 2006 75: 107-111. [Abstract] [Full Text] [PDF]  

Summary: Statins induce a concentration-dependent inhibition of growth of human endometrial stromal cells and decrease phosphorylation of mitogen-activated protein kinase 3/1.

Immunology:

Gisela Soboll, Li Shen, and Charles R. Wira

Expression of Toll-Like Receptors (TLR) and Responsiveness to TLR Agonists by Polarized Mouse Uterine Epithelial Cells in Culture
Biol Reprod 2006 75: 131-139. [Abstract] [Full Text] [PDF]  

Summary: TLRs 1-6 are expressed by uterine epithelial cells and responsive to specific TLR agonists that alter the expression of key chemokines and proinflammatory cytokines that contribute to the defense of the uterus against potential pathogens.

Male Reproductive Tract:

Chitra Lekha Dahia and A. Jagannadha Rao

Demonstration of Follicle-Stimulating Hormone Receptor in Cauda Epididymis of Rat
Biol Reprod 2006 75: 98-106. [Abstract] [Full Text] [PDF]  

Summary: The presence of functional FSH receptor in cells of the cauda epididymis suggests that FSH could be of significance and important in the regulation of epididymal function.

Mechanisms of Hormone Action:

Pete Lohstroh, Hongxing Dong, Jiangang Chen, Nancy Gee, Xiping Xu, and Bill Lasley

Daily Immunoactive and Bioactive Human Chorionic Gonadotropin Profiles in Periimplantation Urine Samples
Biol Reprod 2006 75: 24-33. [Abstract] [Full Text] [PDF]  

Summary: Human chorionic gonadotropin levels in daily, periimplantation urine samples of pregnancy convey information pertaining to trophic activity and pregnancy outcome that may be useful as the basis for an early biomarker for population based studies.

Gilda Cobellis, Giovanna Cacciola, Donatella Scarpa, Rosaria Meccariello, Rosanna Chianese, Maria Fosca Franzoni, Ken Mackie, Riccardo Pierantoni, and Silvia Fasano

Endocannabinoid System in Frog and Rodent Testis: Type-1 Cannabinoid Receptor and Fatty Acid Amide Hydrolase Activity in Male Germ Cells
Biol Reprod 2006 75: 82-89. [Abstract] [Full Text] [PDF]  

Summary: CNR1 and FAAH are present in germinal compartment of frog testis and in isolated spermatozoa.

Minireviews:

John J. Peluso

Multiplicity of Progesterone's Actions and Receptors in the Mammalian Ovary
Biol Reprod 2006 75: 2-8. [Abstract] [Full Text] [PDF]  

Summary: This minireview summarizes the putative receptors and their signal transduction pathways that mediate progesterone's actions in granulosa and luteal cells.

Robert X.-D. Song and Richard J. Santen

Membrane Initiated Estrogen Signaling in Breast Cancer
Biol Reprod 2006 75: 9-16. [Abstract] [Full Text] [PDF]  

Summary: Estrogen, mediated by its receptor ESR1, rapidly activates MAPK1/3 and AKT1 in breast cancer cells. Formation of a large protein complex including ESR1, CSK, SHC1, PELP1 is required to initiate the rapid actions of estrogen.

Ovary:

B. Campbell, J. Dickey, B. Beckman, G. Young, A. Pierce, H. Fukada, and P. Swanson

Previtellogenic Oocyte Growth in Salmon: Relationships among Body Growth, Plasma Insulin-Like Growth Factor-1, Estradiol-17beta, Follicle-Stimulating Hormone and Expression of Ovarian Genes for Insulin-Like Growth Factors, Steroidogenic-Acute Regulatory Protein and Receptors for Gonadotropins, Growth Hormone, and Somatolactin
Biol Reprod 2006 75: 34-44. [Abstract] [Full Text] [PDF]  

Summary: Previtellogenic oocyte growth in the coho salmon is accompanied by significant changes in systemic and intraovarian factors of both the somatotropic and reproductive axes.

Peixin Yang and Shyamal K. Roy

Transforming Growth Factor B1 Stimulated DNA Synthesis in the Granulosa Cells of Preantral Follicles: Negative Interaction with Epidermal Growth Factor
Biol Reprod 2006 75: 140-148. [Abstract] [Full Text] [PDF]  

Summary: TGFB1 through SMAD-MAPK14-PKC signaling stimulates hamster follicular DNA synthesis: however, EGF and TGFB1 together counteract each other's signaling, resulting in a suppression of DNA synthesis.

Peixin Yang and Shyamal K. Roy

A Novel Mechanism of FSH Regulation of DNA Synthesis in the Granulosa Cells of Hamster Preantral Follicles: Involvement of a Protein Kinase C-Mediated MAP Kinase 3/1 Self-Activation Loop
Biol Reprod 2006 75: 149-157. [Abstract] [Full Text] [PDF]  

Summary: FSH- or EGF-induced granulosa cell proliferation in intact preantral follicles depends on a novel PKC-mediated MAPK3/1 self-activation loop.

Pregnancy:

Damien P. Hewitt, Peter J. Mark, Arun M. Dharmarajan, and Brendan J. Waddell

Placental Expression of Secreted Frizzled Related Protein-4 in the Rat and the Impact of Glucocorticoid-Induced Fetal and Placental Growth Restriction
Biol Reprod 2006 75: 75-81. [Abstract] [Full Text] [PDF]  

Summary: Placental expression of SFRP4 occurs predominantly in the nonproliferative basal zone in late pregnancy and is elevated after glucocorticoid-induced placental growth restriction.

N. Lambot, P. Lybaert, A. Boom, J. Delogne-Desnoeck, A.M. Vanbellinghen, G. Graff, P. Lebrun, and S. Meuris

Evidence for a Clathrin-Mediated Recycling of Albumin in Human Term Placenta
Biol Reprod 2006 75: 90-97. [Abstract] [Full Text] [PDF]  

Summary: Maternal albumin is actively internalized into the human trophoblast according to an apical recycling pathway; this temperature-sensitive process does not depend on an intact cytoskeleton but involves a clathrin-mediated endocytotic system.

Francesca Ietta, Yuanhong Wu, Jennifer Winter, Jing Xu, Jinxia Wang, Martin Post, and Isabella Caniggia

Dynamic HIF1A Regulation During Human Placental Development
Biol Reprod 2006 75: 112-121. [Abstract] [Full Text] [PDF]  

Summary: Tight regulation of HIF1A expression is required for proper human placentation.

Reproductive Technology:

Stefan Hiendleder, Michaela Wirtz, Cora Mund, Martina Klempt, Horst-Dieter Reichenbach, Miodrag Stojkovic, Myriam Weppert, Hendrik Wenigerkind, Martin Elmlinger, Frank Lyko, Oliver J. Schmitz, and Eckhard Wolf

Tissue-Specific Effects of In Vitro Fertilization Procedures on Genomic Cytosine Methylation Levels in Overgrown and Normal Sized Bovine Fetuses
Biol Reprod 2006 75: 17-23. [Abstract] [Full Text] [PDF]  

Summary: In vitro fertilization procedures affect hepatic and skeletal muscle but not cerebral cytosine methylation levels in overgrown and normal sized bovine fetuses.

F. Constant, M. Guillomot, Y. Heyman, X. Vignon, P. Laigre, J.L. Servely, J.P. Renard, and P. Chavatte-Palmer

Large Offspring or Large Placenta Syndrome? Morphometric Analysis of Late Gestation Bovine Placentomes from Somatic Nuclear Transfer Pregnancies Complicated by Hydrallantois
Biol Reprod 2006 75: 122-130. [Abstract] [Full Text] [PDF]  

Summary: The morphometry and sterology of placentomes from nuclear transfer cattle shows that placental overgrowth precedes fetal overgrowth and that the placenta drives fetal growth in these cases.

Testis:

Rebecca C. Bott, Ryann M. McFee, Debra T. Clopton, Candice Toombs, and Andrea S. Cupp

Vascular Endothelial Growth Factor and Kinase Domain Region Receptor Are Involved in Both Seminiferous Cord Formation and Vascular Development During Testis Morphogenesis in the Rat
Biol Reprod 2006 75: 56-67. [Abstract] [Full Text] [PDF]  

Summary: VEGFA is involved in both seminiferous cord formation and vasculature development during testis morphogenesis.

Mito Kanatsu-Shinohara, Kimiko Inoue, Hiromi Miki, Narumi Ogonuki, Masanori Takehashi, Takeshi Morimoto, Atsuo Ogura, and Takashi Shinohara

Clonal Origin of Germ Cell Colonies after Spermatogonial Transplantation in Mice
Biol Reprod 2006 75: 68-74. [Abstract] [Full Text] [PDF]  

Summary: Retrovirus-mediated gene delivery and in vitro microinsemination techniques demonstrate the clonal origin of germ cell colonies after spermatogonial transplantation.

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