Highlights:

John Eppig, Mary Ann Handel, and Sue Moenter

Highlights
Biol Reprod 2006 74: 1. [Full Text] [PDF]  

Gamete Biology:

Malini Bajpai, Sarah E. Fiedler, Zaohua Huang, Srinivasan Vijayaraghavan, Gary E. Olson, Gabriel Livera, Marco Conti, and Daniel W. Carr

AKAP3 Selectively Binds PDE4A Isoforms in Bovine Spermatozoa
Biol Reprod 2006 74: 109-118. [Abstract] [Full Text] [PDF]  

Summary: AKAP3 binds both PKA and PDE4A and functions as a scaffolding protein in spermatozoa to regulate local cAMP concentrations and modulate sperm functions.

Sara Matson, Styliani Markoulaki, and Tom Ducibella

Antagonists of Myosin Light Chain Kinase and of Myosin II Inhibit Specific Events of Egg Activation in Fertilized Mouse Eggs
Biol Reprod 2006 74: 169-176. [Abstract] [Full Text] [PDF]  

Summary: MYLK2 and myosin II regulate meiotic spindle rotation, polar body formation, and cortical granule exocytosis in fertilized mouse eggs

D. Nogueira, R. Ron-El, S. Friedler, M. Schachter, A. Raziel, R. Cortvrindt, and J. Smitz

Meiotic Arrest In Vitro by Phosphodiesterase 3-Inhibitor Enhances Maturation Capacity of Human Oocytes and Allows Subsequent Embryonic Development
Biol Reprod 2006 74: 177-184. [Abstract] [Full Text] [PDF]  

Summary: Regulating intra-oocyte phosphodiesterase type 3 activity in vitro may allow the synchronization of nuclear and ooplasmic maturation of human oocytes.

Immunology:

Takeshi Yamaguchi, Kotaro Kitaya, Nobue Daikoku, Tadahiro Yasuo, Shinji Fushiki, and Hideo Honjo

Potential Selectin L Ligands Involved in Selective Recruitment of Peripheral Blood CD16(–) Natural Killer Cells into Human Endometrium
Biol Reprod 2006 74: 35-40. [Abstract] [Full Text] [PDF]  

Summary: The expression pattern of selectin L ligands in the human endometrial endothelium supports the idea that CD16(-) natural killer cells are recruited from peripheral blood into the endometrium.

Thomas M D'Hooghe, Noreen P. Nugent, Silvio Cuneo, Daniel C. Chai, Frank Deer, Sophie Debrock, Cleophas M. Kyama, Attila Mihalyi, and Jason M. Mwenda

Recombinant Human TNFRSF1A (r-hTBP1) Inhibits the Development of Endometriosis in Baboons: A Prospective, Randomized, Placebo- and Drug-Controlled Study
Biol Reprod 2006 74: 131-136. [Abstract] [Full Text] [PDF]  

Summary: Recombinant human TNFRSF1A (r-hTBP1) may be effective in the prevention of endometriosis and endometriosis-related adhesions

Male Reproductive Tract:

C. Pietrement, G-H. Sun-Wada, N. Da Silva, M. McKee, V. Marshansky, D. Brown, M. Futai, and S. Breton

Distinct Expression Patterns of Different Subunit Isoforms of the V-ATPase in the Rat Epididymis
Biol Reprod 2006 74: 185-194. [Abstract] [Full Text] [PDF]  

Summary: Different V-ATPase subunit isoforms are expressed in epididymal epithelial cells and may be involved in targeting the pump to different subcellular compartments.

Mechanisms of Hormone Action:

E.E. At-Taras, A.J. Conley, T. Berger, and J.F. Roser

Reducing Estrogen Synthesis Does Not Affect Gonadotropin Secretion in the Developing Boar
Biol Reprod 2006 74: 58-66. [Abstract] [Full Text] [PDF]  

Summary: Estrogen does not appear to regulate gonadotropin secretion in the developing boar

J. Alejandro Arreguin-Arevalo and Terry. M. Nett

A Nongenomic Action of Estradiol as the Mechanism Underlying the Acute Suppression of Secretion of Luteinizing Hormone in Ovariectomized Ewes
Biol Reprod 2006 74: 202-208. [Abstract] [Full Text] [PDF]  

Summary: Acute nongenomic action of estradiol is possibly mediated at the plasma membrane

Neuroendocrinology:

Kellie M. Breen and Fred J. Karsch

Does Season Alter Responsiveness of the Reproductive Neuroendocrine Axis to the Suppressive Actions of Cortisol in Ovariectomized Ewes?
Biol Reprod 2006 74: 41-45. [Abstract] [Full Text] [PDF]  

Summary: Season does not alter responsiveness of the reproductive neuroendocrine axis to the suppressive actions of stress-like levels of cortisol in ovariectomized ewes.

Ovary:

Céline Moreau, Pascal Froment, Lucie Tosca, Virginie Moreau, and Joëlle Dupont

Expression and Regulation of the SCD2 Desaturase in the Rat Ovary
Biol Reprod 2006 74: 75-87. [Abstract] [Full Text] [PDF]  

Summary: The {Delta}9 SCD2 desaturase is expressed and active in rat ovary and may be involved in the regulation of follicular growth and/or the oocyte maturation

Cadence E Minge, Natalie K. Ryan, Kylie H. Van Der Hoek, Rebecca L. Robker, and Robert J. Norman

Troglitazone Regulates Peroxisome Proliferator-Activated Receptors and Inducible Nitric Oxide Synthase in Murine Ovarian Macrophages
Biol Reprod 2006 74: 153-160. [Abstract] [Full Text] [PDF]  

Summary: Murine ovarian macrophages express peroxisome proliferator-activated receptor (PPAR) mRNA and protein and are responsive to PPAR-activating ligands.

Wendy Jefferson, Retha Newbold, Elizabeth Padilla-Banks, and Melissa Pepling

Neonatal Genistein Treatment Alters Ovarian Differentiation in the Mouse: Inhibition of Oocyte Nest Breakdown and Increased Oocyte Survival
Biol Reprod 2006 74: 161-168. [Abstract] [Full Text] [PDF]  

Summary: Neonatal exposure to the soy phytoestrogen genistein causes disruption of ovarian differentiation, including inhibition of oocyte nest breakdown, retention of oocyte intercellular bridges, attenuation of oocyte cell death, and increased oocyte numbers.

Pituitary:

Marie-Ève Fortin, R.-Marc Pelletier, Mélissa-Anne Meilleur, and Maria Leiza Vitale

Modulation of GJA1 Turnover and Intercellular Communication by Proinflammatory Cytokines in the Anterior Pituitary Folliculostellate Cell Line TtT/GF
Biol Reprod 2006 74: 2-12. [Abstract] [Full Text] [PDF]  

Summary: Proinflammatory cytokines increase GJA1 turnover in FS cells

Pregnancy:

Shlomit Goldman and Eliezer Shalev

Difference in Progesterone-Receptor Isoforms Ratio Between Early and Late First-Trimester Human Trophoblast Is Associated with Differential Cell Invasion and Matrix Metalloproteinase 2 Expression
Biol Reprod 2006 74: 13-22. [Abstract] [Full Text] [PDF]  

Summary: Progesterone-receptor isoforms B:A ratio is higher in early trophoblast cells as compared to late trophoblast; this difference is compatible with an inverse temporal effect of progesterone on trophoblast cells invasion and MMP2 expression

Damien P. Hewitt, Peter J. Mark, and Brendan J. Waddell

Placental Expression of Peroxisome Proliferator-Activated Receptors in Rat Pregnancy and the Effect of Increased Glucocorticoid Exposure
Biol Reprod 2006 74: 23-28. [Abstract] [Full Text] [PDF]  

Summary: Placental expression of PPARG increases in the rapidly growing labyrinth zone over the final third of rat pregnancy but is reduced after glucocorticoid-induced fetal growth restriction.

Deepak Kumar, Willa Fung, Robert M. Moore, Vishal Pandey, Jennifer Fox, Bradley Stetzer, Joseph M. Mansour, Brian M. Mercer, Raymond W. Redline, and John J. Moore

Proinflammatory Cytokines Found in Amniotic Fluid Induce Collagen Remodeling, Apoptosis, and Biophysical Weakening of Cultured Human Fetal Membranes
Biol Reprod 2006 74: 29-34. [Abstract] [Full Text] [PDF]  

Summary: The pro-inflammatory cytokines TNF and or IL1B may be involved in the development of the weak zone of human fetal membranes which overlays the cervix at term.

Denise G. Hemmings, Nicola K. Hudson, Deborah Halliday, Maureen O'Hara, Philip N. Baker, Sandra T. Davidge, and Michael J. Taggart

Sphingosine-1-Phosphate Acts via Rho-Associated Kinase and Nitric Oxide to Regulate Human Placental Vascular Tone
Biol Reprod 2006 74: 88-94. [Abstract] [Full Text] [PDF]  

Summary: Human placental vascular tone can be regulated by the bioactive lipid, sphingosine-1-phosphate, through activation of Rho-associated kinases and Ca2+-sensitization and also through modulation by nitric oxide

J.W. Ward, A.J. Forhead, F.B.P. Wooding, and A.L. Fowden

Functional Significance and Cortisol Dependence of the Gross Morphology of Ovine Placentomes During Late Gestation
Biol Reprod 2006 74: 137-145. [Abstract] [Full Text] [PDF]  

Summary: Ovine placental morphology is cortisol dependent in late gestation and affects glucose delivery to the fetus when fetal cortisol levels are high

C. Rouget, O. Barthez, F. Goirand, M.J. Leroy, M. Breuiller-Fouché, Z. Rakotoniaina, P. Guérard, E.J. Morcillo, C. Advenier, P. Sagot, D. Cabrol, M. Dumas, and M. Bardou

Stimulation of the ADRB3 Adrenergic Receptor Induces Relaxation of Human Placental Arteries: Influence of Preeclampsia
Biol Reprod 2006 74: 209-216. [Abstract] [Full Text] [PDF]  

Summary: Function of ADRB3 adrenergic receptor in human placental arteries is impaired in preeclampsia.

Reproductive Technology:

Pablo Bosch, Scott L. Pratt, and Steven L. Stice

Isolation, Characterization, Gene Modification, and Nuclear Reprogramming of Porcine Mesenchymal Stem Cells
Biol Reprod 2006 74: 46-57. [Abstract] [Full Text] [PDF]  

Summary: Marrow-derived porcine mesenchymal stem cells can be expanded in vitro, genetically modified, and used as nuclear donors to produce somatic cell nuclear transfer embryos and, in the future, to serve as a large animal model for gene and cell therapies.

Olivia Hibbitt, Kevin Coward, Hiroki Kubota, Nilendran Prathalingham, William Holt, Kenjiro Kohri, and John Parrington

In Vivo Gene Transfer by Electroporation Allows Expression of a Fluorescent Transgene in Hamster Testis and Epididymal Sperm and Has No Adverse Effects upon Testicular Integrity or Sperm Quality
Biol Reprod 2006 74: 95-101. [Abstract] [Full Text] [PDF]  

Summary: Expression of a transgene in hamster testis and sperm after in vivo gene transfer by electroporation validates a novel way to study gene function during fertilization in hamsters

Kyung-Bon Lee and Koji Niwa

Fertilization and Development In Vitro of Bovine Oocytes Following Intracytoplasmic Injection of Heat-Dried Sperm Heads
Biol Reprod 2006 74: 146-152. [Abstract] [Full Text] [PDF]  

Summary: Bovine spermatozoa, dried by heating and used for ICSI, can induce oocyte activation and subsequent embryonic development at least as far as the blastocyst stage.

Testis:

Kate L. Loveland, Cathryn Hogarth, Anette Szczepny, Sridurga Mithra Prabhu, and David A. Jans

Expression of Nuclear Transport Importins beta 1 and beta 3 Is Regulated During Rodent Spermatogenesis
Biol Reprod 2006 74: 67-74. [Abstract] [Full Text] [PDF]  

Summary: Regulated expression of nuclear transport proteins correlates with key maturation switches in spermatogenesis.

Shouhua Wang, Huili Zheng, Yumiko Esaki, Fiona Kelly, and Wei Yan

Cullin3 Is a KLHL10-Interacting Protein Preferentially Expressed During Late Spermiogenesis
Biol Reprod 2006 74: 102-108. [Abstract] [Full Text] [PDF]  

Summary: Cullin3 directly binds KLHL10 to form a testis-specific ubiquitin E3 ligase

Xiangfan Zhang, Kevin T. Ebata, Bernard Robaire, and Makoto C. Nagano

Aging of Male Germ Line Stem Cells in Mice
Biol Reprod 2006 74: 119-124. [Abstract] [Full Text] [PDF]  

Summary: Both spermatogonial stem cells and testicular environment contribute to the cessation of spermatogenesis during aging

Francisco Barrionuevo, Stefan Bagheri-Fam, Jürgen Klattig, Ralf Kist, Makoto M. Taketo, Christoph Englert, and Gerd Scherer

Homozygous Inactivation of Sox9 Causes Complete XY Sex Reversal in Mice
Biol Reprod 2006 74: 195-201. [Abstract] [Full Text] [PDF] Supplemental Figure 1  

Summary: Ck19:Cre-mediated inactivation of Sox9 in the gonadal anlagen causes complete XY sex reversal, as shown by expression of the early ovary-specific markers Wnt4 and Foxl2, providing in vivo proof that Sox9 is essential for testogenesis in mice.

Toxicology:

Anita Franczak, Anna Nynca, Kelli E. Valdez, Kemmy M. Mizinga, and Brian K. Petroff

Effects of Acute and Chronic Exposure to the Aryl Hydrocarbon Receptor Agonist 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on the Transition to Reproductive Senescence in Female Sprague-Dawley Rats
Biol Reprod 2006 74: 125-130. [Abstract] [Full Text] [PDF]  

Summary: Aryl hydrocarbon receptor activation accelerates reproductive senescence

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