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This Article Full Text Full Text (PDF) All Versions of this Article: 79/3/459    most recent biolreprod.108.068874v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Moreau, P. Articles by Carosella, E. D. PubMed PubMed Citation Articles by Moreau, P. Articles by Carosella, E. D. Agricola Articles by Moreau, P. Articles by Carosella, E. D.

HLA-G Gene Polymorphism in Human Placentas: Possible Association of G*0106 Allele with Preeclampsia and Miscarriage

Commissariat à l'Energie Atomique,² I²BM, Service de Recherches en Hémato-Immunologie, IUH, Hôpital Saint-Louis, 75475 Paris, France Centro Regionale Trapianti,³ Ospedale R. Binaghi, 09126 Cagliari, Italy Unità di Genetica Umana,⁴ BCS-Biotech, 09131 Cagliari, Italy Cattedra di Genetica Medica,⁵ Università di Cagliari, 09124 Cagliari, Italy Département de Microbiologie et Immunologie,⁶ Centre hospitalier de l'Université de Montréal, Hôpital Notre Dame, Montréal, Canada H2L 4M1 Institut d'Histo-Cyto-Pathologie,⁷ 33495 Le Bouscat, France

ABSTRACT

Definite causes for several pathologies of pregnancy remain unknown. In light of several recent studies, however, diminished or aberrant HLA-G expression may be associated with certain complication of pregnancy and be linked to HLA-G polymorphism. We analyzed DNA from 60 normal placentas (controls), 140 placentas from miscarriage, 36 placentas from preeclampsia, 76 placentas from fetal hypotrophy, and 34 placentas with hypoxia for variations in coding regions (allelic groups G*0101 to G*0107) and the 14-bp deletion/insertion into the 3'-untranslated region. No statistically significant differences were observed in the distribution of allelic group between pathological placentas and controls with the exception of G*0106 allele frequency in preeclamptic compared with control placentas (21.2% and 6.6%, respectively). A greater frequency of this allele also was observed in the two subgroups of miscarriage and hypoxia compared with that in controls. In addition, presence of the 14-bp sequence was prominent in preeclampsia compared with controls (60.8% vs. 35%, respectively), and homozygotes with deletion were not detected in the pathology. The results suggest that the G*0106 allele, which is coupled with the presence of the 14-bp sequence, contributes and/or is a relevant marker in some specific complications of pregnancy, especially preeclampsia.

HLA-G, immunology, placenta, polymorphism, pregnancy, pregnancy disease