Loss of the Protein NUPR1 (p8) Leads to Delayed LHB Expression, Delayed Ovarian Maturation, and Testicular Development of a Sertoli-Cell-Only Syndrome-Like Phenotype in Mice
Biol Reprod Million Passe et al.
10.1095/biolreprod.108.068304
Supplemental Data
Files in this Data Supplement:
Supplemental Figure S1 -
"Loss of Nupr1 does not impact expression of factors indicative of melanotroph function at p2. Expression of factors indicative of melanotroph function is not altered in Nupr1-/- mice. At p2, levels of POMC, which is expressed by corticotrophs and melanotrophs, and &agr;MSH appear similar in the melanotrophs of Nupr1+/+ and Nupr1-/- littermates. Images were taken at 100x magnification."
Supplemental Figure S2 -
"Loss of Nupr1 does not impact numbers of ovarian tertiary follicles or CL. a) The number of tertiary follicles per ovarian section is similar in Nupr1+/+ and Nupr1-/- littermates at eight through ten weeks, when ovaries of Nupr1-/- females lack CL, and at 11-12 weeks, when all ovaries are mature. b) Once all mice reach sexual maturity at 11 weeks, the numbers of CL per ovary section are similar in Nupr1+/+ and Nupr1-/- littermates."
