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Highlights

Nuclear-cytoplasmic conflict issues predict clone success.

There is considerable interest in understanding how interactions between mitochondria and the somatic cell nucleus in cloned embryos affect developmental potential. This is important for interspecies nuclear transfer, where, particularly for non-domestic and exotic species, domestic animal oocytes are used as recipients for exotic donor nuclei. In a study on p. 514, Mastromonaco et al. demonstrate, using an interspecies nuclear transfer, a genetic hybrid Gaur x cattle donor nucleus supports a better rate of development to the blastocyst stage and production of higher quality blastocysts than does a 100% gaur nucleus. This indicates that nucleus-cytoplasm interactions may restrict success of interspecies nuclear transfer embryos. This system may be useful for identifying the specific molecular interactions that support clone development.

Gabriela F. Mastromonaco, Laura A. Favetta, Lawrence C Smith, France Filion, and W. Allan King. The Influence of Nuclear Content on Developmental Competence of Gaur x Cattle Hybrid In Vitro Fertilized and Somatic Cell Nuclear Transfer Embryos. Biol Reprod 2007; 76:514–523. Published online ahead of print 6 December 2006; DOI 10.1095/biolreprod.106.058040

More bad news about ethanol consumption.

The interaction between nutrition and reproduction is understudied and a paper from Wallock-Montelius et al. on p. 455 of this issue introduces the potential impact of life style choices (chronic alcohol consumption). In this study, male Yucatan micropigs were subjected to chronic ethanol consumption with and without dietary folate deficiency. Chronic ethanol consumption impaired spermatogenesis, and folate deficiency reduced circulating testosterone and estradiol; the two treatments had opposite effects on testicular folate metabolism and methionine synthase activity. If these observations are applicable to humans, they might contribute to our understanding of the perceived decline in male reproductive health, raising the possibility that it is not due solely to environmental contaminants but also to what we do to ourselves!

Lynn M. Wallock-Montelius, Jesus A. Villanueva, Robert E. Chapin, A. J. Conley, Hung P. Nguyen, Bruce N. Ames, and Charles H. Halsted. Chronic Ethanol Perturbs Testicular Folate Metabolism and Dietary Folate Deficiency Reduces Sex Hormone Levels in the Yucatan Micropig. Biol Reprod 2007; 76:455–465. Published online ahead of print 6 December 2006; DOI 10.1095/biolreprod.106.053959

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content