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Highlights

Jacqueline M. Wallace, Masatoshi Matsuzaki, John Milne, and Raymond Aitken. Biol Reprod 2006; 75:231–239. Published online ahead of print 10 May 2006; DOI 10.1095/biolreprod.106.052605

Adolescent pregnancy and maternal overnourishment In a paper on p. 231 of this issue, Wallace and colleagues provide important new results from a study of overnourished adolescent sheep in which maternal tissue synthesis has been shown to take priority and result in reduced placental growth and, consequently, a significant decrease in birth weight of the lamb. The authors provide results of a study to determine whether GH can influence fetal growth and body composition by increasing placental size or by altering maternal metabolism. The effects of exogenous GH were on maternal endocrinology, metabolism, and body composition; however, GH also increased fetal growth and fetal adiposity without affecting placental size. The results provide evidence that treatment of ewes with GH during late gestation can partially alleviate intrauterine growth retardation in overnourished primiparous ewes without affecting reduced placental growth that is characteristic of this sheep model for adolescent pregnancy in humans.

Multiple Glycolytic Enzymes are Tightly Bound to the Fibrous Sheath of Mouse Spermatozoa

Michelle Krisfalusi, Kiyoshi Miki, Patricia L. Magyar, and Deborah A. O'Brien. Biol Reprod 2006; 75:270-278. Published online ahead of print 10 May 2006; DOI 10.1095/biolreprod.105.049684

Anchoring metabolism in the sperm A central dogma of cell biology is that structure and function are intimately connected. The fibrous sheath of mammalian spermatozoa is a structure that has long fascinated cell biologists, and now it is emerging that one of its roles may be as a scaffold for metabolic enzymes. Previously, the spermatogenic glyceraldehyde 3-phosphate dehydrogenase had been shown to be associated with the fibrous sheath, and now, in a paper on p. ??? of this issue, Krisfalusi et al. report a directed proteomic study to determine if other glycolytic enzymes are likewise bound to the fibrous sheath. Highly-purified fibrous sheath preparations were subjected to MS/MS peptide analysis, which led to the identification of the aldolase 1, A isoform, lactate dehydrogenase A, and pyruvate kinase as components of the fibrous sheath. Together these data support the concept of the fibrous sheath as a scaffold for enzymatically-active proteins and suggest mechanisms for generating localized production of ATP in the sperm tail-thus, structure begets function.

Related articles in Biol Reprod:

Late but Not Early Gestational Maternal Growth Hormone Treatment Increases Fetal Adiposity in Overnourished Adolescent Sheep

Jacqueline M. Wallace, Masatoshi Matsuzaki, John Milne, and Raymond Aitken
Biol Reprod 2006 75: 231-239. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Biol Reprod Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content