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BOR - Papers in Press, published online ahead of print April 5, 2006.
Biol Reprod 2006, 10.1095/biolreprod.105.047704
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BIOLOGY OF REPRODUCTION 75, 98–106 (2006)
DOI: 10.1095/biolreprod.105.047704
© 2006 by the Society for the Study of Reproduction, Inc.

Research Article

Demonstration of Follicle-Stimulating Hormone Receptor in Cauda Epididymis of Rat1

Chitra Lekha Dahia , and A. Jagannadha Rao 2 

Department of Biochemistry, Indian Institute of Science, Bangalore-560012, India

ABSTRACT

FSH receptor has been shown to be specifically expressed only in the Sertoli cells in males. In one of our studies that consisted of deprival of endogenous FSH in immature rats and adult bonnet monkeys, atrophy of the epididymis was observed, cauda region being the most affected. Although epididymis is an androgen-dependent tissue, the changes in histology of the cauda region were observed without any associated change in the levels of testosterone in FSH-deprived animals. Considering this, it was of interest to evaluate the possibility of epididymis being a direct target for FSH action. In the present study, we have examined the expression of FSH receptor in the epididymis of rat and monkey. In the cauda region of rat epididymis, FSH receptor expression was demonstrated by RT-PCR and Northern and Western blot analyses. FSH receptor was found to be functional as observed by its ability to bind 125IoFSH, by an increase in cAMP production, and by BrdU incorporation following addition of FSH under in vitro conditions. These results suggest the possibility of a role for FSH in regulating the growth of the epididymis.

epididymis, follicle-stimulating hormone, follicle-stimulating hormone receptor, male reproductive tract

FOOTNOTES

1 Supported by the Council of Scientific and Industrial Research (CSIR), Department of Science and Technology, Department of Biotechnology, Indian Council of Medical Research, Government of India, and Mellon and CONDRAD Foundation, USA, and a CSIR Emeritus Scientist Fellowship to A.J.R. Part of this work was presented at the 37th annual meeting of the Society for the Study of Reproduction, 1–4 August 2004, Vancouver, BC, Canada (Abstract 179, p. 133).

2 Correspondence: A. Jagannadha Rao, Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, Karnataka, India. FAX: 91 80 2360 0999; ajrao{at}biochem.iisc.ernet.in






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Copyright © 2006 by the Society for the Study of Reproduction.