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Biology of Reproduction, Vol 30, 537-543, Copyright © 1984 by Society for the Study of Reproduction

ARTICLES

Stimulation and inhibition of rat oocyte meiosis by forskolin

C Ekholm, T Hillensjo, C Magnusson and S Rosberg

The adenylate cyclase activator forskolin was used to study the role of cAMP for oocyte meiosis and follicular steroid secretion. Follicular and cumulus cAMP production was stimulated dose-dependently by forskolin, as was the follicular secretion of progesterone, testosterone and estradiol. Forskolin induced meiosis in follicle- enclosed oocytes with a maximal effect at 1 microM, with lower and higher concentrations being less effective. The spontaneous resumption of meiosis in isolated cumulus-enclosed oocytes was dose-dependently retarded by forskolin. Meiosis of cumulus-free oocytes was also retarded but only slightly. These data support the earlier hypothesis that a limited increase in follicular cAMP levels triggers meiosis, whereas sustained levels of cAMP in the oocyte itself prevent meiosis.


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F. J. Richard, A. Tsafriri, and M. Conti
Role of Phosphodiesterase Type 3A in Rat Oocyte Maturation
Biol Reprod, November 1, 2001; 65(5): 1444 - 1451.
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Copyright © 1984 by the Society for the Study of Reproduction.