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Biology of Reproduction, Vol 29, 1027-1032, Copyright © 1983 by Society for the Study of Reproduction

ARTICLES

Gossypol-induced inhibition of guinea pig sperm capacitation in vitro

QX Shi and DS Friend

The effect of gossypol acetate at various concentrations (10(-6) to 10(- 4) M) on guinea pig sperm forward progressive movement, capacitation, and the acrosome reaction was explored in vitro. We found that 10(-4) M gossypol completely abolished the forward progressive motility of the sperm, and that this inhibition of motility was proportional to the concentration of gossypol used. Also, a dose-dependent decrease in acrosome reactions occurred with concentrations of the agent as low as 5.0 X 10(-6) M. However, we observed that such prevention of the acrosome reaction apparently happens at the capacitation stage rather than during the acrosome reaction itself. Inhibition of capacitation by gossypol was reversible--once the spermatozoa were capacitated in gossypol-free medium, the compound did not block the reaction.


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W. Y. Chen, W. M. Xu, Z. H. Chen, Y. Ni, Y. Y. Yuan, S. C. Zhou, W. W. Zhou, L. L. Tsang, Y. W. Chung, P. Hoglund, et al.
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Biol Reprod, January 1, 2009; 80(1): 115 - 123.
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