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Biology of Reproduction, Vol 14, 544-548, Copyright © 1976 by Society for the Study of Reproduction

The Effects of 17beta-Estradiol and Medroxyprogesterone Acetate Alone and in Combination with agr-Chlorohydrin on Reproductive Function in the Male Rat

DOROTHY M. HUNT 1, C. M. LUBICZ-NAWROCKI 1, , and M. C. CHANG 1

1 Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545


Experiments were designed to test the effects of 17beta-estradiol and medroxyprogesterone acetate (Provera) alone and in combination with agr-chlorohydrin on spermatogenesis, accessory organ weights, mating behavior and fertility in male rats. Fertility was not impaired by daily injections of a subminimal dose of agr-chlorohydrin alone or in combination with 1 mg Provera (one injection per 5 days for 25 days). The total number of implantation sites was significantly reduced in females mated with males receiving 1 mg 17beta-estradiol daily for 5 days and combined treatment with 0.6 mg agr-chlorohydrin/rat/day enhanced this antifertility effect. The 25-day treatment of 17beta-estradiol impaired spermatogenesis, reduced the number of spermatozoa in the epididymis and ductus deferens and prevented further increase in body weight but the effects were reversed and fertility was regained within 10 weeks after the end of treatment.

Note:
ACKNOWLEDGMENTS This work was supported by grants from the Ford Foundation and the NIH, U.S. Public Health Service (HD 03003). Thanks are due to the Upjohn Company for their generous supply of Provera and agr-chlorohydrin. Sincere appreciation is expressed to Mrs. Rose Bartke for assistance with the animals and for carrying out the histology and to Mrs. E. Senior for typing the manuscript.

Submitted on October 31, 1975
Accepted on January 30, 1976






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Copyright © 1976 by the Society for the Study of Reproduction.