| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Biology of Reproduction, Vol 14, 507-509, Copyright © 1976 by Society for the Study of Reproduction
1 Biomedical Division, Population Council,
Rockefeller University, New York, N.Y. 10021 No fall in maternal progesterone values preceding the onset of labor has been demonstrated in
pregnant monkeys in plasma from a peripheral vein, giving rise to the question of how this hormone maintains the uterus in a quiescent state during gestation without blocking parturition. We
wondered whether progesterone levels taken from sites more directly related to the uterus would
yield different results. Plasma progesterone values were determined during the last half of gestation in pregnant monkeys in samples taken from the uterine veins, the umbilical vein, the fetal heart and a maternal
peripheral vein. Peripheral vein levels during this period ranged from 1.3 to 18.0 ng/ml and showed
no trend with advancing gestation. Levels in the uterine vein ranged from 2.2 to 150 ng/ml, in the
unbilical vein from 6.9 to 233 ng/ml, and in the fetal heart from 3.8 to 223 ng/ml. In plasma from
these 3 sites there was a significant trend toward lower values with advancing gestation. Uterine and umbilical vein progesterone levels appear more likely to reflect conditions in the
uterus than maternal peripheral vein levels. Their declining values in the latter part of gestation
suggest that, contrary to the indications afforded by peripheral levels, the pregnant macaque does
not differ from the pregnant rabbit, cow, sheep and rat in experiencing a waning influence of progesterone on the uterus as term approaches.
Note:
ACKNOWLEDGMENTS
This work was supported in part by Grant No.
HDO7290, National Institute of Child Health and Human Development, National Institute of Health.
The authors wish to acknowledge with thanks the
preparation of the 11
-succinyl progesterone-bovine-serum albumin conjugate by Dr. K. Sundaram, the
help of Ms. Linda Seidman and Ms. Emilija Jurevicius,
technicians, and of the animal caretakers of the monkey colony.
This article has been cited by other articles:
|
|
 |
|
  Y. Chen, W. N. Jefferson, R. R. Newbold, E. Padilla-Banks, and M. E. Pepling Estradiol, Progesterone, and Genistein Inhibit Oocyte Nest Breakdown and Primordial Follicle Assembly in the Neonatal Mouse Ovary in Vitro and in Vivo Endocrinology, August 1, 2007; 148(8): 3580 - 3590. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. E Nilsson, J. Stanfield, and M. K Skinner Interactions between progesterone and tumor necrosis factor-{alpha} in the regulation of primordial follicle assembly. Reproduction, December 1, 2006; 132(6): 877 - 886. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kezele and M. K. Skinner Regulation of Ovarian Primordial Follicle Assembly and Development by Estrogen and Progesterone: Endocrine Model of Follicle Assembly Endocrinology, August 1, 2003; 144(8): 3329 - 3337. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
