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Biology of Reproduction, Vol 14, 317-326, Copyright © 1976 by Society for the Study of Reproduction

Progesterone Biosynthesis and Metabolism by Ovarian Follicles and Isolated Oocytes of Xenopus laevis

CATHERINE THIBIER-FOUCHET 1, ODILE MULNER 1, , and RENÉ OZON 1

1 Laboratoire de Physiologie de la Reproduction, Groupe Stéroides, Université Pierre et Marie Curie, 12, rue Cuvier 75005 Paris, France


Ovarian follicles of Xenopus laevis exposed to exogenous radioactive pregnenolone have been observed to synthesize radioactive progesterone. Biochemical evidence demonstrates that the Dgr5-3beta-hydroxysteroid oxydoreductase activity is solely localized in the follicular envelopes. Cyanoketone inhibits HCG induced maturation and also pregnenolone-induced maturation. Evidences are presented which strongly suggest that the conversion of pregnenolone to progesterone is a prerequisite for biological activity.

Progesterone and related steroids are actively metabolized by the ovarian follicle and also by the isolated (after collagenase treatment) oocyte. The results demonstrate that the defolliculated oocyte possess a 17agr-hydroxylase, a C21-19 desmolase, a 20agr-hydroxysteroid oxydoreductase and 5beta/agr-reductases. The two main metabolites isolated, after exposure to progesterone, from the oocyte are androstenedione and 17agr,20agr-dihydroxy-pregn-4-ene-3-one.

Note:
ACKNOWLEDGMENTS This work was supported by the Delegation Generale à la Recherche Scientifique et Technique (D.G.R.S.T.) and the C.N.R.S. (ATP 429 909).

Submitted on August 18, 1975
Accepted on November 12, 1975




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Copyright © 1976 by the Society for the Study of Reproduction.