Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by MOGER, W. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MOGER, W. H.
Agricola
Right arrow Articles by MOGER, W. H.

Biology of Reproduction, Vol 14, 115-117, Copyright © 1976 by Society for the Study of Reproduction

Serum Testosterone Response to Acute LH Treatment in Estradiol Treated Rats

W. H. MOGER 1

1 Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7


The effect of 17beta-estradiol benzoate (E2 B) treatment on serum LH and FSH concentrations and the acute response of serum testosterone concentrations have been examined in intact adult male rats. E2 B treatment (100 µg/day for 3 days) did not alter serum LH concentration or testes weights but did lower FSH levels in 1 of 2 experiments. E2 B treatment significantly decreased ventral prostate weights and serum testosterone concentrations. Acute treatment with NIH-LH-B9 (1-100 µg) resulted in significant increases in serum testosterone in both E2 B treated and control rats but at all doses tested the serum testosterone concentrations obtained in E2 B treated animals were significantly less than in control animals.

This work supports the hypothesis that estradiol has a direct inhibitory effect on testosterone secretion.

Note:
ACKNOWLEDGMENTS The technical assistance of Mr. James Hayes is gratefully acknowledged. The NIH-LH-B9 was the gift of the NIH Pituitary Hormone Distribution Program. This work was supported by Grant MA-5401 from the Medical Research Council of Canada.

Submitted on August 11, 1975
Accepted on September 22, 1975






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1976 by the Society for the Study of Reproduction.