Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 13, 123-125, Copyright © 1975 by Society for the Study of Reproduction

The Relationship Between Zona Digestion and Cortical Granule Disappearance in Rabbit Eggs

Inseminated in vitro

LYNN R. FRASER 1, and PRAMILA V. DANDEKAR 1

1 Department of Obstetrics and Gynecology, Yale School of Medicine, New Haven, Connecticut 06510, U.S.A.


A correlation between the time required for zona pellucida dissolution and the presence or absence of cortical granules was noted in rabbit eggs exposed to sperm in vitro. Eggs with cortical granules required approximately 2 min for zona digestion. Those without cortical granules required an average of 2 to 4 times as long, with those exposed to sperm for a shorter period (1 h) and presumably examined soon after sperm penetration requiring less time than those exposed to sperm for 2-4 h.

Submitted on November 22, 1974
Accepted on March 3, 1975






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Copyright © 1975 by the Society for the Study of Reproduction.